Pattern recognition receptors prrs are proteins capable of recognizing molecules frequently found in pathogens the so called pathogen associated molecular patterns pamps or molecules released by damaged cells the damage associated molecular patterns damps they emerged phylogenetically prior to the appearance of the adaptive immunity and therefore are considered part of the innate . Deterioration of the immune system with age is mostly due to biological factors such as genetics and interactions with environmental factors like exposure to infectious agents including cmv or cytomegalovirus imposing metabolic alterations caused by unhealthy lifestyles poor exercise inadequate diet and prolonged physiological stress 2 3 . Marin lauro juliano et al prevalence and clinical aspects of cmv congenital infection in a low income population virology journal 131 2016 148 liu yingna et al diagnostic utility of ocular symptoms and vision for cytomegalovirus retinitis plos one 1110 2016 e0165564 testing. Infections associated with diseases are those that are associated with possible infectious etiologies that meet the requirements of kochs postulatesother methods of causation are described by the bradford hill criteria and evidence based medicine kochs postulates have been altered by some epidemiologists based upon sequence based detection of distinctive pathogenic nucleic acid sequences
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