Liver regeneration basic mechanisms relevant models and clinical applications presents cutting edge information on liver regeneration research through an integrated systems wide perspective the book addresses discoveries on hepatic progenitor cells liver regeneration after chemical damage and liver regeneration as a prime therapy for liver failure and disease. In this chapter we will discuss the animal models that researchers employ to explore the mechanisms of liver regeneration this includes surgical and chemical models in which hepatocyte proliferation is responsible for regeneration and those that interrogate the contribution of the livers bipotent progenitor cell population hepatic progenitor cells hpcs also known as oval cells . Although the exact mechanisms connecting metabolism and regeneration have not been identified a number of signaling molecules and pathways regulated by metabolism have also been implicated in the control of liver regeneration examples include cytokines epidermal growth factor receptor glycogen synthase kinase 3 mammalian target of rapamycin amp kinase xenobiotic . Liver regeneration mechanisms and models to clinical application 2 3 4 stuart j forbes12 and philip n newsome34 5 6 1 mrc centre for regenerative medicine university of edinburgh edinburgh uk 7 2 scottish liver transplant unit royal infirmary of edinburgh nhs lothian. Liver regeneration is important in both the context of homeostasis and in recovery from disease or injury in this review forbes and newsome describe the mechanisms underlying liver regeneration
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